Hadron Correlation in Jets

We review some recent experimental and theoretical work on the correlation among hadrons produced at intermediate $p_T$ at RHIC. The topics include: forward and backward asymmetry with and without trigger at mid-rapidity, associated-particle distribution on the near side, the $\Omega$ puzzle and its solution, associated particles on the away side, and two-jet recombination at LHC.Comment: Talk given at the 11th Workshop on Correlation and Fluctuation in Multiparticle Production, Hangzhou, China, Nov 21-24, 200

Operator improvement for Ginsparg-Wilson fermions

The improvement of fermionic operators for Ginsparg-Wilson fermions is investigated. We present explicit formulae for improved Green's functions, which apply both on-shell and off-shell.Comment: 13 pages, Latex, 4 postscript figure

Quenched chiral logarithms in lattice QCD with exact chiral symmetry

We examine quenched chiral logarithms in lattice QCD with overlap Dirac quark. For 100 gauge configurations generated with the Wilson gauge action at $\beta = 5.8$ on the $8^3 \times 24$ lattice, we compute quenched quark propagators for 12 bare quark masses. The pion decay constant is extracted from the pion propagator, and from which the lattice spacing is determined to be 0.147 fm. The presence of quenched chiral logarithm in the pion mass is confirmed, and its coefficient is determined to be $\delta = 0.203 \pm 0.014$, in agreement with the theoretical estimate in quenched chiral perturbation theory. Further, we obtain the topological susceptibility of these 100 gauge configurations by measuring the index of the overlap Dirac operator. Using a formula due to exact chiral symmetry, we obtain the $\eta'$ mass in quenched chiral perturbation theory, $m_{\eta'} = (901 \pm 64)$ Mev, and an estimate of $\delta = 0.197 \pm 0.027$, which is in good agreement with that determined from the pion mass.Comment: 24 pages, 6 EPS figures; v2: some clarifications added, to appear in Physical Review

Demonstration of the asymmetric lateral Casimir force between corrugated surfaces in the nonadditive regime

The measurement of the lateral Casimir force between two aligned sinusoidally corrugated Au-coated surfaces has been performed in the nonadditive regime. The use of deeper corrugations also allowed to demonstrate an asymmetry in the phase dependences of the lateral Casimir force, as predicted earlier. The measurement data are found to be in excellent agreement with the exact theoretical results computed at T=300 K including effect of real material properties. The deviations between the exact theory and the proximity force approximation are quantified. The obtained results are topical for applications in nanomachines.Comment: 9 pages, 3 figure

Contact Binary Variables as X-ray Sources

We present cross-identification of archived X-ray point sources with W UMa variable stars found in the All-Sky Automated Survey (ASAS). In a surveyed sky area of 300 square degrees of ASAS, 36 W UMa stars have been found associated with X-ray emission. We compute the distances of these W UMa systems and hence their X-ray luminosities. Our data support the "supersaturation" phenomenon seen in these fast rotators, namely that the faster a W UMa star rotates, the weaker its X-ray luminosity.Comment: 10 pages, 2 figures, 1 table; submitted to A

Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia

Asparagine Synthetase (ASNS) catalyzes the synthesis of the non-essential amino acid asparagine (Asn) from aspartate (Asp) and glutamine (Gln). ASNS expression is highly regulated at the transcriptional level, being induced by both the Amino Acid Response (AAR) and the Unfolded Protein Response (UPR) pathways. Lack of ASNS protein expression is a hallmark of Acute Lymphoblastic Leukemia (ALL) blasts, which, therefore, are auxotrophic for Asn. This peculiarity is the rationale for the use of bacterial L-Asparaginase (ASNase) for ALL therapy, the first example of anti-cancer treatment targeting a tumor-specific metabolic feature. Other hematological and solid cancers express low levels of ASNS and, therefore, should also be Asn auxotrophs and ASNase sensitive. Conversely, in the last few years, several reports indicate that in some cancer types ASNS is overexpressed, promoting cell proliferation, chemoresistance, and a metastatic behavior. However, enhanced ASNS activity may constitute a metabolic vulnerability in selected cancer models, suggesting a variable and tumor-specific role of the enzyme in cancer. Recent evidence indicates that, beyond its canonical role in protein synthesis, Asn may have additional regulatory functions. These observations prompt a re-appreciation of ASNS activity in the biology of normal and cancer tissues, with particular attention to the fueling of Asn exchange between cancer cells and the tumor microenvironment

Considerations in Promoting Parent and Family Involvement

It has been recognized for decades that parent and family (PF) involvement is a vital component of students\u27 educational experiences. Moreover, PF involvement is identified as an important protective factor for students. Thus, school administrators and educators understanding and encouraging positive relationships between families and schools may be one way to promote academic, social, and emotional success for youth throughout their lives. The purpose of this paper is to examine the literature on PF involvement and delineate a proposed model of PF involvement to foster resilience in children and youth

Oligodendroglioma cells lack glutamine synthetase and are auxotrophic for glutamine, but do not depend on glutamine anaplerosis for growth

In cells derived from several types of cancer, a transcriptional program drives high consumption of glutamine (Gln), which is used for anaplerosis, leading to a metabolic addiction for the amino acid. Low or absent expression of Glutamine Synthetase (GS), the only enzyme that catalyzes de novo Gln synthesis, has been considered a marker of Gln-addicted cancers. In this study, two human cell lines derived from brain tumors with oligodendroglioma features, HOG and Hs683, have been shown to be GS-negative. Viability of both lines depends from extracellular Gln with EC of 0.175 ± 0.056 mM (Hs683) and 0.086 ± 0.043 mM (HOG), thus suggesting that small amounts of extracellular Gln are sufficient for OD cell growth. Gln starvation does not significantly affect the cell content of anaplerotic substrates, which, consistently, are not able to rescue cell growth, but causes hindrance of the Wnt/β-catenin pathway and protein synthesis attenuation, which is mitigated by transient GS expression. Gln transport inhibitors cause partial depletion of intracellular Gln and cell growth inhibition, but do not lower cell viability. Therefore, GS-negative human oligodendroglioma cells are Gln-auxotrophic but do not use the amino acid for anaplerosis and, hence, are not Gln addicted, exhibiting only limited Gln requirements for survival and growth

The NASA/GSFC hydrogen maser program: A review of recent data

Data is presented on the phase and frequency stability, over time periods extending to one week, of the new NR field operable hydrogen masers developed by the Applied Physics Laboratory (APL) and the older NX and NP field operable hydrogen masers developed by Goddard Space Flight Center and maintained and upgraded by Bendix Field Engineering Corporation (BFEC). Data is presented on the NR masers in the laboratory showing frequency stabilities well into the 10 to the -15th power range and phase stabilities well into the 100 ps range for periods of up to one day. Data is presented on upgraded NP masers in the laboratory showing that the frequency stability has been improved substantially to virtually the NR level. VLBI data is presented on the phase difference between NX-2 at Owens Valley, California and NR-2 at Fort Davis, Texas for a one week period showing, after removal of a constant frequency drift, a 350 ps RMS phase stability

Survival estimation and testing via multiple imputation

Multiple imputation is a technique for handling data sets with missing values. The method fills in each missing value several times, creating many augmented data sets. Each augmented data set is analyzed separately and the results combined to give a final result consisting of an estimate and a measure of uncertainty. In this paper we consider nonparametric multiple-imputation methods to handle missing event times for censored observations in the context of nonparametric survival estimation and testing. Two nonparametric imputation schemes are considered. In risk set imputation the censored time is replaced by a random draw of the observed times amongst those at risk after the censoring time. In Kaplan–Meier (KM) imputation the imputed time is a draw from the estimated distribution of event times amongst those at risk after the censoring time. We show that with a large number of imputes the estimates from both methods reproduce the KM estimator. In a simulation study we show that the inclusion of a bootstrap stage in the multiple imputation algorithm gives coverage rates of confidence intervals that are comparable to that from Greenwood’s formula. Connections to the redistribute to the right algorithm are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91899/1/Taylor Stat Prob Let 2002.pd